In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's ...

Other Phenotypes Premature death, attributed to hindbrain tauopathy, generally occurs between eight and 12 months (Dutschmann et al., 2010). Premature death is preceded by weight loss, hyperkyphosis, ...

Besides cushioning the brain, CSF washes away waste such as neurotransmitters, metabolites, and proteins, including proteins that aggregate—such as Aβ and tau. After circulating through the brain, CSF ...

To narrow down the number of scents needed for such a test, Li first ranked each of the 16 SST-ID and 40 UPSIT scents for their ability to distinguish PD/DLB from controls in three cohorts—the De Novo ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...

Glymphatic clearance, which relies on a network of astrocytic endfeet arranged along vessels of the cerebrovasculature, has been implicated in AD, though it is not without controversy. Perivascular ...

In a healthy brain, border-associated macrophages within the dura mater and choroid plexus are replaced by circulating monocytes, while those in the leptomeninges and perivascular spaces, and also ...

Monocyte-derived microglia arise from hematopoietic stem cells, which divide throughout a mammal’s lifetime to generate monocytes. Over time, these stem cells accrue mutations, for example in DNM3TA, ...

What’s more, the annexin shrank these neurites, as seen by a reduction in the amount of LAMP1, a lysosomal protein that packs into these membrane swellings. The size or number of amyloid plaques ...