The Chicago Cubs (22-15) host the San Francisco Giants (23-14) in the rubber match of a 3-game series Wednesday. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Patrick Bailey hit a tiebreaking single in San Francisco’s nine-run 11th inning, and the Giants beat the Chicago Cubs 14-5 on Tuesday at Wrigley Field.

The Chicago Cubs have an excellent offense and rank with a .376 wOBA and third with a .220 ISO against left-handed pitchers. Still, Chicago is likely to see a splash of negative regression moving forward, and registering an extra-base hit in 10.5% of its at bats against southpaws is also likely unsustainable.