The Pittsburgh Pirates had an early lead and chances to come back, but a poor sixth inning allowed the St. Louis Cardinals to take the series opene

St. Louis Cardinals infielder Jose Barrero celebrates with teammate Willson Contreras at the end of the dugout on Monday, May 5, 2025, after hitting a home in the third inning of a game against the Pittsburgh Pirates at Busch Stadium in St. Louis.

Willson Contreras hit a go-ahead home run in a four-run sixth inning and the St. Louis Cardinals beat the Pittsburgh Pirates 6-3 on Monday night for their third straight victory.

Preview the May 4 matchup between the Pittsburgh Pirates and San Diego Padres with odds over/under, game spread, betting lines and more.

Pregame analysis and predictions of the San Diego Padres vs. Pittsburgh Pirates MLB game to be played on May 4, 2025 on ESPN.

The Pittsburgh Pirates are at home hosting the San Diego Padres this afternoon at beautiful PNC Park. Please remember our Game Day thread guidelines. Don’t troll in your comments; create conversation rather than destroying it Remember Bucs Dugout is basically a non-profanity site Out of respect to broadcast partners who have paid to carry the game,