Russia warned against efforts to force a regime change in Iran and said it would react “very negatively” if Iran’s Supreme Leader Ayatollah Khamenei were killed, raising concerns of a broader escalation in the Israel-Iran conflict as European leaders came together with Iran on Friday for a diplomatic meeting.

Millions of residents have left Tehran as Israel continues to attack Iran. Main roads have been clogged with traffic as people try to flee the metropolis. At petrol stations, residents have waited in line for hours to fill their vehicles. Shops, banks and businesses have shut.