All night people in Israel have been braced for more rockets. Just before 01:00 the Israeli military announced that it was striking missile sites in Iran, and instructed residents to move closer to shelters. Four hours later the response came – with what felt like the largest barrage so far of this conflict.

The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.

The Israeli military claims its campaign has eliminated high-value targets, including nine senior scientists, and severely damaged Iran’s nuclear infrastructure. Iranian authorities confirmed damage to four critical buildings at the Isfahan uranium conversion facility,

The deadly conflict between Israel and Iran has entered a fourth day, with both sides firing waves of missiles overnight. Follow for live updates.

The Israeli military said that its air force has struck a number of command centers of Iran’s Islamic Revolutionary Guard Corps. It said that the command centers, which were in Tehran, were used to direct proxy groups to launch attacks against Israel.

Iran fired a new wave of missiles at Israel. Authorities reported at least five killed and dozens more wounded in the fourth day of open warfare that showed no sign of slowing.

Israel’s high-tech defences have so far succeeded against most of the hundreds of ballistic missiles fired by Iran.

Ths Israeli air force says it struck and destroyed surface-to-surface missile production sites, detection radar sites, and surface-to-air missile launchers in Tehran. Ths Israeli military has carried out waves of strikes in Iran since early Friday.

The Iron Dome is designed to protect Israeli citizens by launching guided missiles to intercept incoming rockets and other short-range threats in mid-air.