It's Iowa State vs. Houston in a big-time Big 12 college basketball matchup from Texas. Follow for live score updates and highlights from Saturday.

Everything you need to know in order to watch the Houston Cougars take on the Iowa State Cyclones on Saturday, Feb. 22.

Houston sits atop the conference, with Iowa State three games back, tied for third. The Cyclones are hefty 12-point road underdogs in the college basketball odds. Our Iowa State vs Houston predictions have the Cyclones keeping it close with the bounty of points the books have offered.

Despite missing two key players, Iowa State men's basketball had a valiant effort on the road, but it wasn't enough for the Cyclones to topple Houston

Saturday’s Big 12 schedule includes the Houston Cougars (22-4, 14-1 Big 12) versus the Iowa State Cyclones (21-5, 11-4 Big 12), at 2:00 PM ET on ESPN.Buy tickets for Houston vs. Iowa

The Iowa State women’s basketball team has had multiple opportunities this season to knock off a ranked opponent and potentially get off the NCAA Tournament bubble. The Cyclones couldn’t capitalize on their latest opportunity.