Preview the May 5 matchup between the Cleveland Guardians and Washington Nationals with odds over/under, game spread, betting lines and more.

Pregame analysis and predictions of the Cleveland Guardians vs. Washington Nationals MLB game to be played on May 5, 2025 on ESPN.

Guardians update (20-14): They have won five of their last six games after beating Toronto on Sunday to take the three-game series. Steven Kwan, the team leader in batting average and onbase percentage, hit .500 (4 for 8) against the Nationals last year. Lively went 1-0 and Ortiz 0-1 against the Nats last year.

Cleveland Guardians star José Ramírez was back in the lineup for Sunday’s game against the Blue Jays, two days after the third baseman left in the third inning because of a mild right ankle sprain. The six-time All-Star was injured when he stumbled and fell while crossing first base on an infield single.

Guardians star José Ramirez was back in the lineup for Sunday's game against the Blue Jays, two days after the third baseman left in the third inning because of a mild right ankle sprain.